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If new infections due to non-susceptible bacteria or fungi appear during therapy, the antibiotic should be discontinued and should be instituted as indicated by susceptibility testing. It is best avoided during pregnancy and breast-feeding.
Repeated courses and prolonged treatment should be avoided as they result in overgrowth of non-susceptible organisms.
Ophthalmic ointment may retard corneal healing.
In very rare instances, cases of aplastic anemia were observed after topical long term treatment (> 3 months) with chloramphenicol.
